Founded in 2005, and located both in France (Montpellier) and in Germany (Berlin), HISTALIM provides services in designing, carrying out and validating innovative techniques and assay protocols in histology, immunohistochemistry, in situ hybridization and image analysis, for accelerating and facilitating the development of groundbreaking pharmaceuticals, medical devices and diagnostic tools.
We are mainly working for life sciences and healthcare companies, but also for dermo-cosmetic companies, food industry and environmental organizations. We are particularly engaged in developing new therapies (e.g., therapeutic antibodies) and diagnostic tools (e.g. companion diagnostics) in the areas of oncology, autoimmune diseases, and cardiovascular pathology. We are GLP compliant and authorized to carry out studies on human tissue samples and we have experience in processing and analyzing artificial tissues (e.g., reconstructed epidermis) and inert materials (e.g., artificial organs, implants, biocompatible polymers…).
We work with life sciences and healthcare companies in a variety of application areas:
Early discovery: drug target identification and validation studies, biomarker identification and validation studies, proof of concept studies (all of them can be performed on animal model or on human normal and diseased tissues)
Preclinical studies: quantitative and morphometric analysis of predictive/pharmacodynamics/efficacy biomarkers in preclinical animal models, comparative pathology analyses, efficacy studies, toxicology studies
Clinical trials: human tissues processing and analysis by board certified pathologists using morphological analysis and/or immunolabeling, quantitative analysis of pharmacodynamics and predictive biomarkers in human tissue samples, histopathological scoring system
Biomarker/Companion Diagnostics development
We use the most modern tools and technologies, having heavily invested in latest histology / immunohistochemistry equipment to provide our clients with highly reliable results and cost-effective solutions. For example, immunohistochemistry staining is performed using automata that guarantee a constant quality and allow a fast processing of a large number of human or animal tissue samples. One of our particular strengths consists in having our own in-house research and development activity, to be continuously able to provide our clients with even more innovative technologies and services in tissue imaging.
We take an active role in collaborative research programs and in strategic partnerships with researchers and experts from many different fields. We also work continuously with a European network of pathologists (more than 25 pathologists) that conduct our histopathological examinations. Members of that network have a range of expertise in diverse subspecialty fields of pathology. We finally have an international network of biobanks (15 biobanks throughout the world) to provide our clients with some of the rarest normal and diseased human tissues.